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Nutramax Denamarin with SAMe is a nutritional supplement used to improve your pet's liver function by increasing liver glutathione levels. Glutathione is the liver's major detoxifying agent. Denamarin contains SAMe, a potent antioxidant that also helps protect liver cells from cell death and may help cell repair and regeneration. Denamarin also has Silybin, the most active part of an extract from milk thistle, which acts as an antioxidant and stimulates the flow of bile through the liver to aid in the digestion and absorption of nutrients from your pet's diet. Silybin also helps with liver cell regeneration and may enhance levels of glutathione. The tablets come in three different strengths: for cats and small dogs, for medium dogs, and for large dogs. Each package contains 30 tablets. Our inventory turns over weekly so expiration dates and freshness are the absolute best available.